Express Scripts, for example, uses more than 20 million pounds of ice per year! Pfizer samples (for eligible HCPs) . Click the topic below to receive emails when new articles are available. These may also have special . You've successfully added to your alerts. Store at room temperature 68 to 77F (20 to 25C). III. For reference, refrigerated temperature is 36F to 46F and room temperature is 59F to 77F or 86F (depending on the product). 5HV^UY]M+\le]Rn e^Jw5}bOE.M5c"XO+&1Dj>.vFX Up to a maximum of one month, insulin should be refrigerated at a temperature between 36 degrees and 46 degrees Fahrenheit. [2] For example, two days after receiving a pneumococcal polysaccharide vaccination that had not been refrigerated, a patient developed dizziness, racing heart, jerking of the limbs, and "pins and needles" from head to toe, resulting in a persistent and significant disability. Ergonovine maleate: Tight, light-resistant container at 15-30C. The following AANA Journal course discusses anesthesia-related medications that require refrigeration and how long potency and safety is maintained out of the refrigerator and pro& _&V4.A#j7B WG 3 CJ ] q E '}e MeSH Frozen antibiotics thawed in the refrigerator and extemporaneously compounded medications were excluded. Another study by Tu et al. For example, diazepam loses 25% of its potency when stored over 98F. Store in refrigerator at 2 to 8 C. Cold IVIG can cause more serious side effects. There are also some definitions in the WHO Guidance: Store frozen: transported within a cold chain and stored at -20C (4F). If epinephrine, for example, is exposed to repetitive heating and cooling, it can lose 64% of its efficacy. However, for highly temperature sensitive medications, a pharmacy may utilize a freezer unit without an automatic defrost cycle. Would you like email updates of new search results? Methods: Although not all of these drugs were in short supply, the unnecessary waste of very expensive drugs drives the cost of treatment higher than necessary. drug stability; drug storage; medication errors; pharmaceutical preparations; refrigeration; safety. Electric medication storage boxes are available and for long expeditions are a reasonable solution. The pharmacist, or pharmacy assistant, should personally hand this to the patient while verbally emphasizing the importance of the temperature issue. [7] compiled written information from drug manufacturers about the room-temperature storage of 83 medications labeled for refrigeration. Information was compiled and arranged in tabular format. Stability and compatibility of histamine H2-receptor antagonists in parenteral nutrition mixtures. This is one of the most common storage room requirements for medications because most medications are designed to retain stability at room temperature. Learn More About our Premixes. Bookshelf Liquid vaccines containing an aluminum adjuvant permanently lose potency when exposed to freezing temperatures. doi: 10.1093/ajhp/zxab297. x]K$q, W.P@=x#\>H>3==LWsvz?B7# !%a)bDf"!3*~Yi.nO^:kdu G!7'mQ|;3]gWD3YBdgmLT>n}}l~Tu%}NuX]u!7mjDEYuW/.>OP'dmsfW2RR,D?W+HlM]kt Medications were included in the review if they were labeled to be stored at 2-8 C and purchased by the pharmacy department for uses indicated on the hospital formulary. official website and that any information you provide is encrypted Click here to return to Infusion Pharmacy Update. This type of unit has severe temperature control and stability issues. Temperature ranges for all prescription medications are readily available from various sources, including section 16 of the Full Prescribing Information document, which usually accompanies each prescription. Disclaimer. The site is secure. 8. This pattern happened often until I learned how to better deal with the issue of the temperature sensitivity of my medication. Methods: During May and June of 2006, the prescribing information for medications labeled for refrigeration as obtained from the supplier were reviewed for data addressing room-temperature storage. %PDF-1.4 Room Temperature. Conclusion: MeSH terms Drug Stability* Stability of Common Insulins in Vials and Pens1,2 ! The loss of efficacy can result in many issues compromising the health of the patient. To avoid this, many providers suggest storing the bottle of insulin you are using at room temperature. If you need to carry your medication with you (traveling or just during the length of the day), use a medication cooler. Storage Temperature. Results: ) Refrigerate at 36 to 46 F (2 to 8C). Am J Health Syst Pharm. sharing sensitive information, make sure youre on a federal November 3, 2010 at 2:15 pm. Newer evidence suggests that 1 mg/mL solutions may be stored at room temperature for 3 days or . Store lyophilized Activase at controlled room temperature not to exceed 30C (86F). Cox L, et al. So, I continued to use the same insulin for several days. Careers. Insulin kept at room temperature will last approximately one month. Insulin - stable at room temperature for 28 days (<86F). endstream endobj 151 0 obj <>/Metadata 29 0 R/Outlines 51 0 R/Pages 148 0 R/StructTreeRoot 56 0 R/Type/Catalog>> endobj 152 0 obj <>/MediaBox[0 0 612 792]/Parent 148 0 R/Resources<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 153 0 obj <>stream When parked, do not keep your medication inside a hot car; it can also get above 140F inside a parked car. It can get above 140F in a mailbox on a hot summer day. Since six manufacturers were unable to provide information for 10 medications, only 79 medications were included in the review. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. For example, diazepam loses 25% of its potency when stored over 98F. The table is intended to be used as a guide when temperature excursion occurs, e.g. This table may help to avoid unnecessary drug loss and expenditures due to improper storage temperatures. Remember, ENBREL can be kept at room temperature between 68F to 77F for up to 30 days, which means you may be able to travel for up to 4 weeks with ENBREL without needing to keep it refrigerated. Victor Cohen,1,2 Samantha P. Jellinek,1 Leftherios Teperikidis,1 Elliot Berkovits,1 William M. Goldman 1,2 1Maimonides Medical Center, Brooklyn, NY 2Long Island University, Brooklyn, NY. With over 30 years experience in providing professional sensor solutions our pharma-mon line of products are tailored specifically for the needs of the pharmaceutical industry. Medications that should be refrigerated should be kept between 36 and 46F at all times. It was a metaphoric 8-hour chain to refrigeration. Please enable it to take advantage of the complete set of features! Of the 189 medications listed in AHFS Drug Information 2006 for storage in a . 1989;23(4):197-207. doi: 10.1007/BF00451642. Commenting is limited to medical professionals. The U.S. Pharmacopeia's Med-marx medication-error-reporting system has received nearly 1000 reports involving errors associated with refrigerated medications. If they have any change in form, if the coating appears different, or if the pills are stuck together, the integrity of the medication is likely compromised. endstream endobj 154 0 obj <>stream OZ?.  Know the safe temperature storage range for each of your medications. Refrigeration of medications is often required to maintain medication stability and increase a drug's shelf life. If insulin is cloudy, it is compromised. kk._Q??u!uY6[[E[j! Clipboard, Search History, and several other advanced features are temporarily unavailable. There is thus no need to increase the dose of the toxin within that 4-week period, and it can be used with the confidence that its potency will not have . This article covers how to protect your medications from a variety of elements and what to do if they are exposed to potentially harmful temperatures. Am J Health Syst Pharm. Results: Of the 189 medications listed in AHFS Drug Information 2006 for storage in a refrigerator, 89 were present in the pharmacy department's refrigerator. 1uO*75#]ONkO ) GGt4UuvZ7OxVMVzRIz/&u[E6-YN8V |$}UC-Rr3%4w4>{VJ9 bRXkFQZ%8*LJ\Ve->PF_A^M P8w.uM after 24 hours of storage at room- temperature, when stored in a cool place (8-15 C), and when stored at room-temperature (15-30 C). Stability of Refrigerated Drugs Rx Response. Do not freeze and avoid direct light. Augmentin Suspension - degrades at room temperature and develops a brown discoloration. PMC Like . [1], Inappropriate vaccine storage has been implicated in numerous reports of vaccine-related adverse events. Some patients assume that their insulin always needs to be refrigerated. stream The data were obtained through a survey of manufacturers. Despite my best efforts, I apparently did not always replace the ice in time. Stability data were requested for storage at room temperature (15-30C), in a cool place (8-15 C), and under refrigeration (2-8 C) after 24 hours at controlled room temperature. There is, however, no greater daily challenge than making sure that my insulin is kept cool and safe. endstream endobj 40 0 obj <>>> endobj 41 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[0.0 0.0 585.0 783.0]/Type/Page>> endobj 42 0 obj <>stream %PDF-1.7 % In 2006, Cobos Campos et al. Please enter a Recipient Address and/or check the Send me a copy checkbox. Bookshelf Would you like email updates of new search results? By first becoming as knowledgeable as possible on this important subject and then passing on that knowledge to the patient, the trusted pharmacist is in a unique position to provide this important service to those that he or she serves. To comment please, Comments on Medscape are moderated and should be professional in tone and on topic. Sucrose-based formulations require low primary drying temperatures to avoid collapse and monoclonal antibody (mAb) containing products need to be stored refrigerated. Method: The study included all drugs available in the pharmacy service from August 17, 2004 to October 15 of the same year, date in which the review was performed, that had to be kept at a temperature ranging between 2 degrees and . Pharmacist's Letter/ Prescribers Letter. Z8Q]{lCR)EU4u:/uug83YR/^dL P?062v*6>As5>) ,]'bHK80Ume4xWTJy$yI p7[I?ruO[P8kW,]6-tg4IE&()LV l=-V4{d]|O American Society of Health-System Pharmacists 2022. Now, 27 years after my diagnosis, I am still without complications, but it has not been easy. At room temperature, the degradation rate constant was 1.2%/month for the 20 mg/ml solution and 2.1%/month for the 50 mg/ml solution. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Refrigerated anesthesia-related medications. Lorazepam loses 75% of its potency at that temperature. When flying, never pack medications in check-in luggage. The aim of this review was to build upon previous literature describing the maximum duration for which refrigerated medications can tolerate room temperature excursions while maintaining stability and potency. Sometimes the specifications are a bit more complicated. Do not use if change in appearance. Some medications must be refrigerated while stored in the pharmacy. N7 qlEv:F}Py,:+YJ?{$`EQ5m&/]$feCEUaVTVGuB+4k[G Molecular composition was analysed using nuclear magnetic resonance spectroscopy. Please confirm that you would like to log out of Medscape. Federal government websites often end in .gov or .mil. This chart details the stability of the most commonly dispensed refrigerated drug products (based on the U.S. top 200 prescription medications in 2014), and over-the-counter insulin products. `7#Hg,'/tA@aIe- '!9m "Z9 FOIA Purpose: Data regarding the recommended maximum duration that refrigerated medications available in hospital pharmacies may be stored safely at room temperature were collected and compiled in a tabular format. Candidate . The risks are great if any medication is compromised by exposure to temperatures beyond its safe range. Although the mail order pharmacy puts in enough ice and insulation to account for that day of heat, it does not account for cooling when the medication is in the mailbox for several days. to determine the stability of amoxicillin trihydrate- clavulanate hb```M~ cc`aq@a/O(C" H82t*\S, j2UFMzCD(ztZh PZa0J i`1@ 2022 Jul 8;79(14):1123-1124. doi: 10.1093/ajhp/zxac127. Amgen 800-772-6436 Formoterol (Foradil) Prior to dispensing, refrigerate at 36 to 46 F (2 to 8C). Please enter a Recipient Address and/or check the Send me a copy checkbox. 2008 Nov;30(11):2075-87. doi: 10.1016/j.clinthera.2008.11.013. The objective of this study was to provide an updated table of the maximum acceptable duration that medications labeled for refrigeration may be stored at room-temperature. And, the same guidelines quite clearly state that "allergen immunotherapy extract should be stored at 4 degrees centigrade to reduce the rate of potency loss." These guidelines review studies looking at the stability of extract. Then re-store it immediately. :IsuT$*UB"o7vvMsY/U$ZbOrw}'9s(n*U/q{TH?ctqNc5hQ26w_[Q-NR5\J#hGgrKFJQ!h7YGW3?-{[4/vMhKI>HAwz@>,f2Tr :X$`F# Ld]\=x^O$K"/#ut]E8^+J%u :#=&~$yj[S&H)3UI%d'Yq. 0 A user-restricted, peer-to-peer discussion board that allows open discussion in near-real time. Our best performing cooler can hold 2 Trulicity pens. [|l+] and transmitted securely. The stability of captopril and carbamazepine extemporaneously prepared suspension at 4C and room temperature was studied. 8600 Rockville Pike <> It is also beneficial to patients if the pharmacy can provide practical tips as to how to keep their medication cool. Pharmacists can improve patient adherence by providing education on the importance of keeping medications within proper temperature range. Before HTn@y\W)iV>E} \"Pn~}g%%eyY9gf-r p CEc40T/||| 2007 May;10(3):311-7. doi: 10.1097/MCO.0b013e3280ebb427. Any break in cold-chain storage can potentially affect the safety and efficacy of a medication that requires special temperature requirements. It cannot be assumed that the patient already knows. We were specifically interested in learning about conditions that may result in unnecessary waste of drugs during the ongoing drug shortage crisis or waste of very expensive medications given the ever rising cost associated with healthcare. searchable by keywords and functional areas. Bortezomib is one example. It was only after I went to the pharmacy, spent a great deal of money, and replaced the insulin (insulin, beyond the prescribed dose, is not covered by insurance) that I was able to bring things back into control. Always keep your medication in your carry-on bag. You will receive email when new content is published. Update on room-temperature stability of drug products labeled for refrigerated storage. Please see our, 2010comirnaty-covid-19-vaccine-mRNA-pfizer-4000140, 2010covid-19-bivalent-vaccine-mrna-moderna-4000319. All rights reserved. Of the top 10 medications prescribed, all have upper temperature limits. Famotidine in D5W and in 0.9% Sodium Chloride: Physically compatible with no potency loss in 14 days at 4C. Now. In this system, lorazepam retained 90% of its original concentration for 150 days of on-ambulance storage. Stability Calculator. On the Challenges of Anesthesia and Surgery During Interplanetary Spaceflight. Store in a refrigerator, 2 to 8C (36 to 46F). GI bleeding, MI, stroke IMPLEMENTATION PO route Administer to patient crushed or whole; 800-mg tab may be dissolved in water Give with food or milk to decrease gastric symptoms; give 2 hr before or 30 min after meals; absorption may be slowed Shake susp well before use Store at room temperature Do not use in pregnancy after . Many medications have recommended storage at room temperature, defined as between 68 and 77F. hbbd```b`` 1DnJ` \"bX2}H2) n["@{ +^ h*Fc C Some arent aware of the temperature constraints at all. PLANNING PACKING CHECKPOINTS TRAVEL KIT Many medications suggest storage at "room temperature" of 15 to 30 C (59 to 86 F). The diluted solution is stable for 24 hours at room temperature. ISMP Medication Safety Alert! Acute Care Edition. Stability of solutions of antineoplastic agents during preparation and storage for in vitro assays. No a. FlexPro 30 mg/3 mL. Room temperature is defined as 68 to 77 F. Additionally, the definition extends to between 20 and 25 degrees Celsius. 186 0 obj <>stream V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= It cannot be assumed that the physician told the patient. Do not place medications in an area of sunlight. The au- Product found to be stable after a freeze-thaw cycle Paragon Bio Teck, Inc 503-465-3802 Crotalidae Immune Fab (CroFab) Unreconstituted vials remain stable if exposed to 10C to +2C during 1 continuous excursion of 12 hr BTG International, Inc 877-377-3784 Digoxin Immune Fab (DigiFab) Bethesda, MD 20894, Web Policies Originally prepared by: Brandon Flohr Pharm.D. To evaluate storage stability, freshly fabricated samples were placed into graduated tubes and kept at room temperature or in a refrigerator at ~4 C, sealed to prevent evaporation. 5 0 obj Online ahead of print. Methylergonovine maleate: 2 . H\@=OQEn$dy ! .|1=( |nr]zMtxXk!:?^rt:wn/6]rO6go'c?[\B_k}.t/i-P7qSEVH*}WecH^,T\er1],9 +"2"u6-N}}\ /#ay. Once reconstituted, the manufacturer recommends use within 8 hours. If a compromised dose of epinephrine is used to treat a patient suffering from a serious anaphylactic reaction, it may not work as intended, resulting in possible death. Frozen antibiotics thawed in the refrigerator and extemporaneously compounded medications were excluded. Objective: To review the maximum stability of thermolabile drugs at room temperature (22-25 degrees C) in order to quickly act in case of breakage of the cold chain. Prescription drug expenditures: An employer perspective. Succinylcholine is stable for 30 days at room . I have type 1 diabetes mellitusand have had it since 1986. Diversity in pharmacy residency recruitment. Accessibility These same medications also allow for temporary excursion periods ranging as low as 59F and as high as 86F. H|TMo0+>*8`>WrhJRS5[MF Opened at Room or Refrigerator Temperature (days)1 Unopened at Room Temperature (days)1 Image . One source states that Keflex (cephalexin) suspension can be left out at room temperature for up to 24 hours with no effect on stability. It is important to note that there can still be a decrease in efficacy even if there is not a visible difference. Careers. If you log out, you will be required to enter your username and password the next time you visit. It is observed that many drug products labeled for refrigerated storage are stable at room temperature for extended periods. This information was then compiled into a table for use as a guide to control drug storage within the authors' institution. ugD Copyright 2000 - 2023 Jobson Medical Information LLC unless otherwise noted. The data were obtained through a survey of manufacturers. Before V=% U%` 5 The U.S. Pharmacopeia's definition of room temperature (20-25 degrees C [68-77 degrees F]) was used for this review. U.S. Department of Health & Human Services, Review Select Technical Assistance Responses. % Telephone surveys of the products' manufacturers were conducted when this information was not available in the prescribing information. Stored in the original container, sealed from humidity, and at a temperature no greater than 77 degrees Fahrenheit, dronabinol is good for 3 months outside the fridge. After 0, 1, 3, 7 and 14 days of storage, the stability of the emulsions was examined via visual inspection and was assessed by droplet size and zeta potential. SPT. Victor Cohen; Samantha P. Jellinek; Leftherios Teperikidis; Elliot Berkovits; William M. Goldman. No a. a All unused Norditropin products must be refrigerated (36F to 46F) prior to first use. These same medications also allow for temporary "excursion" periods ranging as low as 59F and as high as 86F. It provides evidence-based information on a variety of topics important to patient care. Federal government websites often end in .gov or .mil. Refrigeration of medications is often required to maintain medication stability and increase a drug's shelf life. I consider myself fortunate as I have been able to maintain good glycemic control over the years. In our business, we frequently receive calls from patients who are completely unaware of the upper temperature limit for their medicationsand this is the select segment of the population that has the presence of mind to inquire about a cooler. 2. Any break in cold-chain storage can potentially affect the safety and efficacy of a medication that requires special temperature requirements. Accessibility Off-label information indicates stable when maintained at room temperature for up to 6 . Fortunately, the supply chain for temperature-sensitive medications in the UnitedStates has proved to be safe. 2007 Aug 15;64(16):1711-5. doi: 10.2146/ajhp060262. 1. The U.S. Pharmacopeia's definition of room temperature (20-25 degrees C [68-77 degrees F]) was used for this review. The GC conditions were: carrier gas, high-purity helium; flow rate, 2.25 mL/min; oven temperature program, hold of the initial temperature at 100C for 1.5 min, ramp up to 280C at a rate of 25 C/min and the final hold for 15 min to give the total running time of 23.7 min; solvent delay time, 7.5 min; forward inlet temperature, 250C . Reconstituted Vial/Powder: Notes: P-Insert Updated: . IVIG should always be infused at room temperature. Results: Since six manufacturers were unable to provide information for 10 medications, only 79 medications were included in the review. Drug: Stability Refrigerated: Stability Room Temp. This table may help to avoid unnecessary drug loss and expenditures due to improper storage temperatures. Cancer Chemother Pharmacol. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Our scientific content is evidence-based, scientifically balanced and non-promotional. When temperature excursion data was unavailable in published form, product manufacturers were surveyed via telephone and/or email. It is with the patient, because of lack of awareness and adherence, where there is the greatest opportunity for medications to lose their efficacy due to exposure to heat. wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 Diluted famotidine injection has been shown to be physically and chemically stable for 7 days at room temperature. When stored at room temperature or in the emergency physician transport vehicle, lorazepam became unstable within weeks, whereas succinylcholine chloride and cisatracurium besylate became unstable within months. Please see our. Unauthorized use of these marks is strictly prohibited. We conducted the survey to learn more about what resources pharmacists rely on to guide drug storage, stability, and beyond use dating. government site. If approved, the option to store at -25C to -15C (-13F to 5F) for two weeks would be in addition to this five-day option to store at standard refrigerator temperature. Vials may be held up to 12 months upon removal from refrigeration to room temperature storage conditions (20C to 25C [68F to 77F], USP Controlled Room Temperature), anytime within the labeled shelf life. Once diluted for administration, each dose should be used within 24 hours. Browse Our Ready-to-Use Portfolio Visit Our eServices Call to Order: 1.888.229.0001. A unit that contains a freezer compartment within the refrigerator space, such as a dorm-style refrigerator, is not permitted. Information related to acceptable periods of room temperature excursion was compiled for a total of 214 products approved for US distribution since 2000. Reconstituted Vial/Powder: powder Notes: Refrigeration of reconstituted solution may result in the formation of a precipitate which will redissolve at room temperature. Norepinephrine, 4 mcg/mL or 16 mcg/mL, in NS or D5W, was stable for up to 7 days at room temperature and ambient light. Temperatures above and beyond this range can have a significant effect on each medication. Responses . It is vital that the pharmacist educate each patient on the temperature specifications of their medication. 2007American Society of Health-System Pharmacists. endstream endobj 155 0 obj <>stream When driving, keep your medication in the climate-controlled interior of the car, not the trunk. Baxter's manufacturer-prepared premixes are convenient and ready when you need them, potentially shortening the time between ordering and administration. And most medications must be stored at a controlled room temperature of around 68 to 77 degrees F once you get them. The time taken for the original concentration of potassium clavulanate to drop to 90% of its value at room temperature of 20C is 2 days (Mehta et al., 2008). Also, remember that once ENBREL reaches room temperature, you cannot put it back in the fridge. My insulin looked the same, was not warm when I inspected it, and was obviously still workingat least to some degree. <> The stability at room temperature of many pharmaceutical products labeled for storage under refrigeration is presented. I discovered that the most practical way for me to keep my insulin cool was with an evaporative medication cooler. Improper storage of these suspensions might not only affect stability, but also the flavor or pourability of the product. Insulin vials. Temperatures above and beyond this range can have a significant effect on each medication. Pharma-Mon by AKCP. HHS Vulnerability Disclosure, Help Uses for Rocuronium Skeletal Muscle Relaxation Am J Health Syst Pharm. ISMP Medication Safety Alert2012Institute for Safe Medication Practices. Cohen V, Jellinek SP, Teperikidis L, Berkovits E, Goldman WM. Store medications in the coolest area of the house. The U.S. Pharmacopeia's. Unopened and stored in this. It is recommended that, if not used immediately after preparation, diluted solutions should be refrigerated and used within 48 hours. Room temperature: 15C to 25C. Sucrose is a common cryoprotectant and lyoprotectant to stabilize labile biopharmaceuticals during freeze-drying and storage. Methylergonovine maleate: Tight, light-resistant container at <25C. An official website of the United States government. Guidelines CERVIDIL must be kept frozen until use and is stable when stored in a freezer for a period of 3 years There is no need for previous warming of the product Insert immediately after removal from its foil package CERVIDIL does not require sterile conditions CERVIDIL must not be used without its retrieval system Purpose: Provides access to Technical Assistance Specialists for one-on-one support. Refrigerated and/or frozen storage of medications is typically performed to maintain medication stability for longer durations and increase the product shelf life. s hX Most pharmaceutical plants execute the manufacturing and packaging of cold chain products at room temperature (15-25 C) using the allocated time out of storage (TOS) established by stability studies. 2007 Aug 15;64(16):1711-5. doi: 10.2146/ajhp060262. However, it is the area between these extremes of temperature that is most interesting. Stability studies to support product handling during preparation and transport The manufacturer must document temperature influence during handling of intermediates, bulk products, packed products until they are stored in the defined final storage conditions. Insulin, for example, has a specification that it cannot exceed 86F. The .gov means its official. Store at 2-8C (36-46F): for heat sensitive products that must not be frozen. Amgen 800-772-6436 Formoterol (Foradil) Prior to dispensing, refrigerate at 36 to 46 F (2 to 8C). Inspect your medications before you take them. National Library of Medicine Find BICILLIN L-A medical information: . Many sterilants and disinfectants must be stored below 30 C (86 F). Some assume that regardless of how long it is stored, it just needs to be kept below 86F. The site is secure. %%EOF Subanesthetic Ketamine for Acute Pain in Critically Ill Patients, FDA Grants Accelerated Approval for Controversial Novel Alzheimers Drug, Analgesia and Sedation Strategies in COVID-19 Patients, New Guidelines Shore Up Smart Infusion Pump Safety. Although manufacturers recommend storing your insulin in the refrigerator, injecting cold insulin can sometimes make the injection more painful.