Endocrinology 2008, 149:22412250. Gestionar el consentimiento de las cookies. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. I don't think so. A distorted idea of human nature is sold when people are treated as "the market. It is very tormenting (for me anyhow) to not know why I got this disease. Methods: The study group included 35 patients (15 women, 20 men, 65.8 7.1 years) with NSCLC in stage IIIB (n = 16, 45.7%) and IV (n = 19,54.3%) who were treated with nivolumab. Monaldi Arch Chest Dis 2003, 59:140145. Endocrinology 1985, 117:12011208. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. J. Clin. Not what people like me are saying. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new disease case the patient is converted into a lifelong customer. Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. Nope. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism? A place for patients and relatives. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. Garlic Beats Drug in Detoxifying Lead Safely From How Yoga and Acupuncture Enhance HealthNew Resear Health Nuts: Seeds And Nuts You Should Eat Every Day. I have been reading Izabella Wentz. [4], More recently DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. Thanks, I am not suggesting I believe in all that I see. JavaScript is disabled. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. Monaldi Arch Chest Dis 2003, 59:140145. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. I cried with joy when I found out there was something really wrong with me. 2 Hypothyroidism is the most common type of thyroid disorder, and women's risk of hypothyroidism is five to eight times higher than that of . But I for one, do appreciate anything that other members forward about potential links, causes, aids to healing, whatever you can them. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. Article published in Wakeup-World.Com. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. [13] Hollowell JG, Staehling NW, Flanders WD, et al. A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. Another recently approved drug is tepotinib (Tepmetko). Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Non-ASPS articles which could be relevant. PMID 11836274. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called subclinical hypothyroidism only detected via blood work. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. 500+ pages of Natural Medicine Alternatives and Information. LOL. The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. Clin Cancer Res 2011, 30:77. "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. ", Cure Alveolar Soft Part Sarcoma International, COMPLETED - Dana Farber Vaccine Clinical Trial (GVAX), Axitinib and Pembrolizumab (Keytruda) in Miami, US, TECENTRIQ (atezolizumab) by Genentech, Treatment of Non-Resectable Primary Tumor, Immune checkpoint inhibitors ICI (PD-1 and PD-L1 targeting drugs), Toxicity, problems and potentiation strategies, Treatment response criteria and evaluation/scanning problems/rare cases, treatment discontinuation/re-treatment, Side effects/complications of the local ablations, High intensity focused ultrasound (HIFU), Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, http://www.greenmedinfo.com/blog/study- ng-cancers. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c Iodine - and the lack of it - is implicated in breast cancer, after all. Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. A total of 425 inpatients with malignant tumors were treated with ICIs at PUMCH during the study period. This discussion has been closed to comments. However, that information will still be included in details such as numbers of replies. PMID: 15253676. I am having a lot of trouble making any sense of this study. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Unfortunately, it's quite typical. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. SayerJiis founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, SteeringCommittee Memberof the Global Non-GMO Foundation. undefined will no longer be visible to you including posts, replies, and photos. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new 'disease' case the patient is converted into a lifelong customer. I read somewhere about the work done many years ago which was mistakenly read and accepted 28 y/o F Low levels across the board for TSH, T3, and T4, Acid reflux drug linked to more than doubled risk of stomach cancer study, thyroiduk.org - further-reading - thyroid-diagnosis-and-treatment. In my view the paper isn't worth the pixels used to display it on a screen. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. [12] Cesarone MR, Belcaro G, Nicolaides AN, Incandela L, De Sanctis MT, Barsotti A: San Valentino epidemiologic project. However, I do not believe it was out of the blue now. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. Angiology 2000, 51:S65S68. weight loss, anorexia). " Untreated hypothyroidism increases morbidity and mortality. Share your experience, learn from others. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. See more of Keri Topouzian, D.O. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. I'm just saying the evidence presented in this article isn't very strong, and more study is needed to show Synthroid causes lung cancer. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. Breast cancer has surpassed lung cancer as the most commonly diagnosed cancer worldwide, according to GLOBOCAN. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. 2002 Feb ;25(2):106-9. It looks at correlations, as if they had any merit on their own. In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. Very interesting article, thank you for sharing. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. I am going to go for a walk with my dog :)). END TIME NEWS, A CALL FOR REPENTANCE, YESHUA THE ONLY WAY TO HEAVEN. I wish I could say that my story was atypical. People read a study and think that someone like, perhaps me, is saying "it Causes lung cancer. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. But what can be done for patients who are at low In my opinion, the science of the study doesn't support the conclusion. For a better experience, please enable JavaScript in your browser before proceeding. and our Sub-laboratory hypothyroidism and the empirical use of Armour thyroid.Altern Med Rev. Increased sensitivity to cold. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. Post At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore back up causing excessive T4 activity, i.e. video where the doc is talking about the study , i wlll link study and video below. They found no significant correlation between T4 sales and breast, colorectal and gastriccancers, but did find a significant correlation for lung cancer (p < 0.05) corrected forsmoking and age. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. Objectives: To examine site-specific cancer incidence and mortality and to evaluate the radiation dose-response association after RAI treatment for hyperthyroidism. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. Subclinical hypothyroidism is defined by an elevated serum thyroid-stimulating hormone (TSH) level along with a normal free thyroxine (T4) level. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight.